New formulations from Acacia nilotica L and Glycyrrhiza glabra L. for oral ulcer remedy

This study addresses the innovation of a stable new pharmaceutical formulation comprising natural botanical extracts of Acacia nilotica L. and Glycyrrhiza glabra L., which are therapeutically effective in the treatment of oral ulcer and possess high patient acceptability. The pastes are prepared, characterized, and subjected to physical and chemical stability studies and then evaluated for therapeutic efficacy regarding ulcer size. The novel adhesive paste is prepared and when applied to the oral mucosa, it remains on it for a considerable period of time. The stability tests of all the samples in the analysis showed satisfactory physical and chemical stability evaluated by the Normal Stability Test. The muco adhesive paste incorporating the active; A. nilotica L, when applied to oral ulcer, could promote the healing process, leading to a decrease in diameter of the inflammatory halo of the ulcer. However, the effect of liquorice extract on recurrent aphthous ulceration [RAU] was found even better than that of acacia extract. A combination of the two plants presented a synergism of both, leading to better healing with favorable reduction of the diameter of inflammatory halo of the ulcer together with a prolonged action. Therapeutically, effective and stable oral pastes are dispensed with cost-effective benefits

Inclusion complexes of meloxicam and cyclodextrins

The interaction of meloxicam with cyclodextrins was investigated. The formation of a 1:1 inclusion complex with hydroxy propyl beta-cyclodextrin and a 1:2 complex with beta-cyclodextrin was established. Characterization was conducted by FTIR spectroscopy, XRD, TGA and [1]H-NMR spectroscopy studies. The solubility increased by increasing pH from 1.2-6.8. The dissolution rates revealed enhanced dissolution properties of the cyclodextrin complexes compared to the drug. The partition between n-octanol and 0.1 N HCI or Mclvaine's citric acid phosphate buffer, revealed that the partition coefficient of meloxicam is higher compared to complexes with cyclodextrins. The present study denotes the capability of forming a more soluble product of meloxicam, at physiologic pH, via complexation with cyclodextrins which would result in enhanced bioavailability and improved efficacy